anno tool module anno.tl

anno tool module anno.tl#

Alignment#

motif_msa

Align motif sequences using progressive MSA or pairwise reference alignment.

sample_msa

Multiple sequence alignment of motif arrays across samples.

Motif Abundance#

motif_abundance_pca

PCA on motif abundance percentage vectors.

Haplotype Calling#

haplotype_neighbor

Build a fused kNN graph from aligned motif arrays for haplotype analysis.

haplotype_leiden

Cluster samples into haplotypes using Leiden on the fused graph.

haplotype_leiden_res_scan

Scan Leiden resolution and record cluster counts + modularity.